Long Term Side Effects of Proton Pump Inhibitors (PPIs)

These are some of the most common drugs used to treat heartburn and acid reflux – Aciphex, Prevacid, Nexium, Prilosec and Protonix.  They were intended to be used short term (12 weeks or less) to block stomach acid.  PPIs are now available over the counter, without a prescription.  What happens if you end up taking these drugs long term (months or years)?  Here are the risks:

Osteoporosis and low B-12 levels.  Researchers found a link between long-term use of PPIs and hip, spine, and wrist fractures.  PPIs affect the body’s absorption of calcium.   It is worse if you are a post menopausal woman or a smoker.  These drugs may also affect vitamin B-12 levels.

A Connection to C. difficile.  Clostridium difficile is a bacterium that causes colitis, an inflammation of the lining of the colon.  The main risk factors for C. diff are old age and the use of antibiotics.  Studies have now shown a connection between C. diff and PPIs, with or without antibiotic use.  People get C. diff by swallowing it.

Anything over 12 weeks is considered long term.  The problem with PPIs, is that the longer you take them, the worse the effects.  A study found that hip fracture risk increased by 35% after taking PPI’s for two years, 42% after four years, and 55% after six to eight years.

What can you do?

Take Back Your Health.  Quit smoking.  Lose weight.  Exercise.  Avoid trigger foods.

What if that’s not enough?

Find out what is causing the reflux in the first place.  That’s where Functional Medicine testing comes in.  Have a consult with Gregg and explore your options for testing what is in your gut and how to treat it.

Smoking and Your Musculoskeletal Health

I had a patient ask a few weeks ago why she wasn’t recovering from an injury faster.  This patient is a heavy smoker.  I tactfully tried to tell her that her smoking was probably causing her delayed healing.  That prompted me to make this list.  I turned it into a handout and posted the list in the office.


When you think of smoking, it is easy to think about increased cancer risks and heart attacks. But how does smoking affect your musculoskeletal system? Here are the dirty dozen.
1.    Increases risk for disc herniation by 50%.
2.    Increases risk for degenerative disc disease.
3.    Increases sensitivity to pain.
4.    Impairs ligament healing.
5.    Impairs bone (fracture) healing.
6.    Decreases muscle mass.
7.    Decreases immunity.
8.    Predisposes to musculoskeletal injury.
9.    Leads to poor outcomes of orthopedic surgery.
10.  Risk factor for osteoporosis, bone loss, and fractures.
11.  Doubles the risk for rheumatoid arthritis.
12.  Increases cartilage loss.


Welcome to the McCoy Chiropractic BLOG!  Visit our website doctorsmccoy.com for information about our office.  This blog is a place for us to post information about health, exercise, diet, and of course chiropractic.  This will be similar to what we post on our Facebook Page.

Doctors Gregory and Michelle McCoy are husband and wife chiropractors that met in chiropractic school.  Their office is located in Jefferson Valley, New York in a renovated farm house.  Their casual and comfortable office has private treatment rooms and friendly office staff.

Michelle McCoy, DC, DICCP is Board Certified in Clinical Chiropractic Pediatrics and Pregnancy and Webster Technique Certified.  She treats patients of all ages.

Gregory McCoy, DC treats professional, college, and other amateur athletes including cyclists, baseball players, runners, gymnasts, and triathletes.